Celiac Disease (CD) is a human enteropathy caused by a permanent intolerance to gluten and, more specifically, to its protein fraction, called gliadin. In genetically-predisposed people, ingesting this protein induces a severe lesion of the intestinal mucosa characterised histologically by crypt hyperplasia with total or subtotal atrophy of the intestinal villi. Definitive diagnosis of celiac disease is based on the typical histological changes observed in intestinal biopsies. However, serologic tests such as detection of circulating anti-gliadin, anti-tTG and anti-endomysial antibodies represent cheaper, less invasive analysis methods to detect this disease.
Simple CD2WB is an immunochromatographic test designed to detect, in human blood, IgA-type antibodies against human tissue transglutaminase (tTG), the main autoantigen recognised by the anti-endomysial antibodies, and antibodies against gliadins. Its use is particularly indicated in the case of pediatric patients (up to 16 years old).
CD2 (Anti tTG – anti gliadin) WB